CX3CR1 is dysregulated in blood and brain from schizophrenia patients.
Identifieur interne : 003091 ( Main/Exploration ); précédent : 003090; suivant : 003092CX3CR1 is dysregulated in blood and brain from schizophrenia patients.
Auteurs : Aurélie Bergon [France] ; Raoul Belzeaux [France] ; Magali Comte [France] ; Florence Pelletier [France] ; Mylène Hervé [France] ; Erin J. Gardiner ; Natalie J. Beveridge ; Bing Liu [Australie] ; Vaughan Carr [Australie] ; Rodney J. Scott ; Brian Kelly [Australie] ; Murray J. Cairns ; Nishantha Kumarasinghe [Sri Lanka] ; Ulrich Schall ; Olivier Blin [France] ; José Boucraut [France] ; Paul A. Tooney ; Eric Fakra [France] ; El Chérif Ibrahim [France]Source :
- Schizophrenia research [ 1573-2509 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse sur microréseau, Encéphale (métabolisme), Femelle, Humains, Marqueurs biologiques (métabolisme), Mâle, Neuroleptiques (usage thérapeutique), Réaction de polymérisation en chaine en temps réel, Récepteurs aux chimiokines (métabolisme), Régulation négative, Schizophrénie (métabolisme), Schizophrénie (traitement médicamenteux), Études de cohortes.
- MESH :
- métabolisme : Encéphale, Marqueurs biologiques, Récepteurs aux chimiokines, Schizophrénie.
- traitement médicamenteux : Schizophrénie.
- usage thérapeutique : Neuroleptiques.
- Adulte, Adulte d'âge moyen, Analyse sur microréseau, Femelle, Humains, Mâle, Réaction de polymérisation en chaine en temps réel, Régulation négative, Études de cohortes.
English descriptors
- KwdEn :
- Adult, Antipsychotic Agents (therapeutic use), Biomarkers (metabolism), Brain (metabolism), Cohort Studies, Down-Regulation, Female, Humans, Male, Microarray Analysis, Middle Aged, Real-Time Polymerase Chain Reaction, Receptors, Chemokine (metabolism), Schizophrenia (drug therapy), Schizophrenia (metabolism).
- MESH :
- chemical , metabolism : Biomarkers, Receptors, Chemokine.
- chemical , therapeutic use : Antipsychotic Agents.
- drug therapy : Schizophrenia.
- metabolism : Brain, Schizophrenia.
- Adult, Cohort Studies, Down-Regulation, Female, Humans, Male, Microarray Analysis, Middle Aged, Real-Time Polymerase Chain Reaction.
Abstract
The molecular mechanisms underlying schizophrenia remain largely unknown. Although schizophrenia is a mental disorder, there is increasing evidence to indicate that inflammatory processes driven by diverse environmental factors play a significant role in its development. With gene expression studies having been conducted across a variety of sample types, e.g., blood and postmortem brain, it is possible to investigate convergent signatures that may reveal interactions between the immune and nervous systems in schizophrenia pathophysiology. We conducted two meta-analyses of schizophrenia microarray gene expression data (N=474) and non-psychiatric control (N=485) data from postmortem brain and blood. Then, we assessed whether significantly dysregulated genes in schizophrenia could be shared between blood and brain. To validate our findings, we selected a top gene candidate and analyzed its expression by RT-qPCR in a cohort of schizophrenia subjects stabilized by atypical antipsychotic monotherapy (N=29) and matched controls (N=31). Meta-analyses highlighted inflammation as the major biological process associated with schizophrenia and that the chemokine receptor CX3CR1 was significantly down-regulated in schizophrenia. This differential expression was also confirmed in our validation cohort. Given both the recent data demonstrating selective CX3CR1 expression in subsets of neuroimmune cells, as well as behavioral and neuropathological observations of CX3CR1 deficiency in mouse models, our results of reduced CX3CR1 expression adds further support for a role played by monocyte/microglia in the neurodevelopment of schizophrenia.
DOI: 10.1016/j.schres.2015.08.010
PubMed: 26285829
Affiliations:
- Australie, France, Sri Lanka
- Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur
- Marseille, Sydney
- Université d'Aix-Marseille
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Le document en format XML
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Gardiner</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Beveridge, Natalie J" sort="Beveridge, Natalie J" uniqKey="Beveridge N" first="Natalie J" last="Beveridge">Natalie J. Beveridge</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Liu, Bing" sort="Liu, Bing" uniqKey="Liu B" first="Bing" last="Liu">Bing Liu</name><affiliation wicri:level="3"><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Kids Cancer Alliance, Cancer Institute NSW, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Kids Cancer Alliance, Cancer Institute NSW, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Carr, Vaughan" sort="Carr, Vaughan" uniqKey="Carr V" first="Vaughan" last="Carr">Vaughan Carr</name><affiliation wicri:level="1"><nlm:affiliation>Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; School of Psychiatry, University of New South Wales, Randwick, NSW 2301, Australia; Department of Psychiatry, Monash University, Clayton, VIC 3168, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; School of Psychiatry, University of New South Wales, Randwick, NSW 2301, Australia; Department of Psychiatry, Monash University, Clayton, VIC 3168</wicri:regionArea><wicri:noRegion>VIC 3168</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kelly, Brian" sort="Kelly, Brian" uniqKey="Kelly B" first="Brian" last="Kelly">Brian Kelly</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305</wicri:regionArea><wicri:noRegion>NSW 2305</wicri:noRegion></affiliation></author><author><name sortKey="Cairns, Murray J" sort="Cairns, Murray J" uniqKey="Cairns M" first="Murray J" last="Cairns">Murray J. Cairns</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kumarasinghe, Nishantha" sort="Kumarasinghe, Nishantha" uniqKey="Kumarasinghe N" first="Nishantha" last="Kumarasinghe">Nishantha Kumarasinghe</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; University of Sri Jayewardenepura, Nugegoda, Sri Lanka; National Institute of Mental Health, Angoda, Sri Lanka.</nlm:affiliation><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; University of Sri Jayewardenepura, Nugegoda, Sri Lanka; National Institute of Mental Health, Angoda</wicri:regionArea><wicri:noRegion>Angoda</wicri:noRegion></affiliation></author><author><name sortKey="Schall, Ulrich" sort="Schall, Ulrich" uniqKey="Schall U" first="Ulrich" last="Schall">Ulrich Schall</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Blin, Olivier" sort="Blin, Olivier" uniqKey="Blin O" first="Olivier" last="Blin">Olivier Blin</name><affiliation wicri:level="1"><nlm:affiliation>CIC-UPCET et Pharmacologie Clinique, Hôpital de la Timone, 13005 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIC-UPCET et Pharmacologie Clinique, Hôpital de la Timone, 13005 Marseille</wicri:regionArea><wicri:noRegion>13005 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Boucraut, Jose" sort="Boucraut, Jose" uniqKey="Boucraut J" first="José" last="Boucraut">José Boucraut</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil</wicri:regionArea><wicri:noRegion>94000 Créteil</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Tooney, Paul A" sort="Tooney, Paul A" uniqKey="Tooney P" first="Paul A" last="Tooney">Paul A. Tooney</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Fakra, Eric" sort="Fakra, Eric" uniqKey="Fakra E" first="Eric" last="Fakra">Eric Fakra</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, CNRS, Institut de Neurosciences de la Timone UMR 7289, 13005 Marseille, France; CHU de Saint-Etienne, Pôle de Psychiatrie, 42100 Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, Institut de Neurosciences de la Timone UMR 7289, 13005 Marseille, France; CHU de Saint-Etienne, Pôle de Psychiatrie, 42100 Saint-Etienne</wicri:regionArea><wicri:noRegion>42100 Saint-Etienne</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Ibrahim, El Cherif" sort="Ibrahim, El Cherif" uniqKey="Ibrahim E" first="El Chérif" last="Ibrahim">El Chérif Ibrahim</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France. Electronic address: el-cherif.ibrahim@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil</wicri:regionArea><wicri:noRegion>94000 Créteil</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26285829</idno><idno type="pmid">26285829</idno><idno type="doi">10.1016/j.schres.2015.08.010</idno><idno type="wicri:Area/PubMed/Corpus">002904</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002904</idno><idno type="wicri:Area/PubMed/Curation">002835</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002835</idno><idno type="wicri:Area/PubMed/Checkpoint">002835</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002835</idno><idno type="wicri:Area/Ncbi/Merge">002950</idno><idno type="wicri:Area/Ncbi/Curation">002950</idno><idno type="wicri:Area/Ncbi/Checkpoint">002950</idno><idno type="wicri:Area/Main/Merge">003092</idno><idno type="wicri:Area/Main/Curation">003091</idno><idno type="wicri:Area/Main/Exploration">003091</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CX3CR1 is dysregulated in blood and brain from schizophrenia patients.</title><author><name sortKey="Bergon, Aurelie" sort="Bergon, Aurelie" uniqKey="Bergon A" first="Aurélie" last="Bergon">Aurélie Bergon</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, TAGC UMR_S 1090, 13288 Marseille Cedex 09, France; Aix Marseille Université, TAGC UMR_S 1090, 13288 Marseille Cedex 09, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, TAGC UMR_S 1090, 13288 Marseille Cedex 09, France; Aix Marseille Université, TAGC UMR_S 1090, 13288 Marseille Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Belzeaux, Raoul" sort="Belzeaux, Raoul" uniqKey="Belzeaux R" first="Raoul" last="Belzeaux">Raoul Belzeaux</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France; AP-HM, Hôpital Sainte Marguerite, Pôle de Psychiatrie Universitaire Solaris, 13009 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France; AP-HM, Hôpital Sainte Marguerite, Pôle de Psychiatrie Universitaire Solaris, 13009 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Comte, Magali" sort="Comte, Magali" uniqKey="Comte M" first="Magali" last="Comte">Magali Comte</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, CNRS, Institut de Neurosciences de la Timone UMR 7289, 13005 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, Institut de Neurosciences de la Timone UMR 7289, 13005 Marseille</wicri:regionArea><wicri:noRegion>13005 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Pelletier, Florence" sort="Pelletier, Florence" uniqKey="Pelletier F" first="Florence" last="Pelletier">Florence Pelletier</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil</wicri:regionArea><wicri:noRegion>94000 Créteil</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Herve, Mylene" sort="Herve, Mylene" uniqKey="Herve M" first="Mylène" last="Hervé">Mylène Hervé</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil</wicri:regionArea><wicri:noRegion>94000 Créteil</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Gardiner, Erin J" sort="Gardiner, Erin J" uniqKey="Gardiner E" first="Erin J" last="Gardiner">Erin J. Gardiner</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Beveridge, Natalie J" sort="Beveridge, Natalie J" uniqKey="Beveridge N" first="Natalie J" last="Beveridge">Natalie J. Beveridge</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Liu, Bing" sort="Liu, Bing" uniqKey="Liu B" first="Bing" last="Liu">Bing Liu</name><affiliation wicri:level="3"><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Kids Cancer Alliance, Cancer Institute NSW, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Kids Cancer Alliance, Cancer Institute NSW, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Carr, Vaughan" sort="Carr, Vaughan" uniqKey="Carr V" first="Vaughan" last="Carr">Vaughan Carr</name><affiliation wicri:level="1"><nlm:affiliation>Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; School of Psychiatry, University of New South Wales, Randwick, NSW 2301, Australia; Department of Psychiatry, Monash University, Clayton, VIC 3168, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; School of Psychiatry, University of New South Wales, Randwick, NSW 2301, Australia; Department of Psychiatry, Monash University, Clayton, VIC 3168</wicri:regionArea><wicri:noRegion>VIC 3168</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kelly, Brian" sort="Kelly, Brian" uniqKey="Kelly B" first="Brian" last="Kelly">Brian Kelly</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305</wicri:regionArea><wicri:noRegion>NSW 2305</wicri:noRegion></affiliation></author><author><name sortKey="Cairns, Murray J" sort="Cairns, Murray J" uniqKey="Cairns M" first="Murray J" last="Cairns">Murray J. Cairns</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kumarasinghe, Nishantha" sort="Kumarasinghe, Nishantha" uniqKey="Kumarasinghe N" first="Nishantha" last="Kumarasinghe">Nishantha Kumarasinghe</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; University of Sri Jayewardenepura, Nugegoda, Sri Lanka; National Institute of Mental Health, Angoda, Sri Lanka.</nlm:affiliation><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia; University of Sri Jayewardenepura, Nugegoda, Sri Lanka; National Institute of Mental Health, Angoda</wicri:regionArea><wicri:noRegion>Angoda</wicri:noRegion></affiliation></author><author><name sortKey="Schall, Ulrich" sort="Schall, Ulrich" uniqKey="Schall U" first="Ulrich" last="Schall">Ulrich Schall</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Blin, Olivier" sort="Blin, Olivier" uniqKey="Blin O" first="Olivier" last="Blin">Olivier Blin</name><affiliation wicri:level="1"><nlm:affiliation>CIC-UPCET et Pharmacologie Clinique, Hôpital de la Timone, 13005 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIC-UPCET et Pharmacologie Clinique, Hôpital de la Timone, 13005 Marseille</wicri:regionArea><wicri:noRegion>13005 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Boucraut, Jose" sort="Boucraut, Jose" uniqKey="Boucraut J" first="José" last="Boucraut">José Boucraut</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil</wicri:regionArea><wicri:noRegion>94000 Créteil</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Tooney, Paul A" sort="Tooney, Paul A" uniqKey="Tooney P" first="Paul A" last="Tooney">Paul A. Tooney</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy and School of Medicine and Public Health, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308 Australia; Centre for Translational Neuroscience and Mental Health, The University of Newcastle, Callaghan, NSW 2308 Australia; Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia; Schizophrenia Research Institute, Darlinghurst, NSW 2010 Australia.</nlm:affiliation><wicri:noCountry code="subField">NSW 2010 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Fakra, Eric" sort="Fakra, Eric" uniqKey="Fakra E" first="Eric" last="Fakra">Eric Fakra</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, CNRS, Institut de Neurosciences de la Timone UMR 7289, 13005 Marseille, France; CHU de Saint-Etienne, Pôle de Psychiatrie, 42100 Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, Institut de Neurosciences de la Timone UMR 7289, 13005 Marseille, France; CHU de Saint-Etienne, Pôle de Psychiatrie, 42100 Saint-Etienne</wicri:regionArea><wicri:noRegion>42100 Saint-Etienne</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Ibrahim, El Cherif" sort="Ibrahim, El Cherif" uniqKey="Ibrahim E" first="El Chérif" last="Ibrahim">El Chérif Ibrahim</name><affiliation wicri:level="4"><nlm:affiliation>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil, France. Electronic address: el-cherif.ibrahim@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Université, CNRS, CRN2M UMR 7286, 13344 Marseille Cedex 15, France; FondaMental, Fondation de Recherche et de Soins en Santé Mentale, 94000 Créteil</wicri:regionArea><wicri:noRegion>94000 Créteil</wicri:noRegion><orgName type="university">Université d'Aix-Marseille</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author></analytic><series><title level="j">Schizophrenia research</title><idno type="eISSN">1573-2509</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antipsychotic Agents (therapeutic use)</term><term>Biomarkers (metabolism)</term><term>Brain (metabolism)</term><term>Cohort Studies</term><term>Down-Regulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Microarray Analysis</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Receptors, Chemokine (metabolism)</term><term>Schizophrenia (drug therapy)</term><term>Schizophrenia (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse sur microréseau</term><term>Encéphale (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques (métabolisme)</term><term>Mâle</term><term>Neuroleptiques (usage thérapeutique)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Récepteurs aux chimiokines (métabolisme)</term><term>Régulation négative</term><term>Schizophrénie (métabolisme)</term><term>Schizophrénie (traitement médicamenteux)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Receptors, Chemokine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antipsychotic Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphale</term><term>Marqueurs biologiques</term><term>Récepteurs aux chimiokines</term><term>Schizophrénie</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Schizophrénie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Neuroleptiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Down-Regulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Microarray Analysis</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse sur microréseau</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Régulation négative</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The molecular mechanisms underlying schizophrenia remain largely unknown. Although schizophrenia is a mental disorder, there is increasing evidence to indicate that inflammatory processes driven by diverse environmental factors play a significant role in its development. With gene expression studies having been conducted across a variety of sample types, e.g., blood and postmortem brain, it is possible to investigate convergent signatures that may reveal interactions between the immune and nervous systems in schizophrenia pathophysiology. We conducted two meta-analyses of schizophrenia microarray gene expression data (N=474) and non-psychiatric control (N=485) data from postmortem brain and blood. Then, we assessed whether significantly dysregulated genes in schizophrenia could be shared between blood and brain. To validate our findings, we selected a top gene candidate and analyzed its expression by RT-qPCR in a cohort of schizophrenia subjects stabilized by atypical antipsychotic monotherapy (N=29) and matched controls (N=31). Meta-analyses highlighted inflammation as the major biological process associated with schizophrenia and that the chemokine receptor CX3CR1 was significantly down-regulated in schizophrenia. This differential expression was also confirmed in our validation cohort. Given both the recent data demonstrating selective CX3CR1 expression in subsets of neuroimmune cells, as well as behavioral and neuropathological observations of CX3CR1 deficiency in mouse models, our results of reduced CX3CR1 expression adds further support for a role played by monocyte/microglia in the neurodevelopment of schizophrenia.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Sri Lanka</li></country><region><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li><li>Sydney</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><noCountry><name sortKey="Beveridge, Natalie J" sort="Beveridge, Natalie J" uniqKey="Beveridge N" first="Natalie J" last="Beveridge">Natalie J. Beveridge</name><name sortKey="Cairns, Murray J" sort="Cairns, Murray J" uniqKey="Cairns M" first="Murray J" last="Cairns">Murray J. Cairns</name><name sortKey="Gardiner, Erin J" sort="Gardiner, Erin J" uniqKey="Gardiner E" first="Erin J" last="Gardiner">Erin J. Gardiner</name><name sortKey="Schall, Ulrich" sort="Schall, Ulrich" uniqKey="Schall U" first="Ulrich" last="Schall">Ulrich Schall</name><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><name sortKey="Tooney, Paul A" sort="Tooney, Paul A" uniqKey="Tooney P" first="Paul A" last="Tooney">Paul A. Tooney</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Bergon, Aurelie" sort="Bergon, Aurelie" uniqKey="Bergon A" first="Aurélie" last="Bergon">Aurélie Bergon</name></region><name sortKey="Belzeaux, Raoul" sort="Belzeaux, Raoul" uniqKey="Belzeaux R" first="Raoul" last="Belzeaux">Raoul Belzeaux</name><name sortKey="Blin, Olivier" sort="Blin, Olivier" uniqKey="Blin O" first="Olivier" last="Blin">Olivier Blin</name><name sortKey="Boucraut, Jose" sort="Boucraut, Jose" uniqKey="Boucraut J" first="José" last="Boucraut">José Boucraut</name><name sortKey="Comte, Magali" sort="Comte, Magali" uniqKey="Comte M" first="Magali" last="Comte">Magali Comte</name><name sortKey="Fakra, Eric" sort="Fakra, Eric" uniqKey="Fakra E" first="Eric" last="Fakra">Eric Fakra</name><name sortKey="Herve, Mylene" sort="Herve, Mylene" uniqKey="Herve M" first="Mylène" last="Hervé">Mylène Hervé</name><name sortKey="Ibrahim, El Cherif" sort="Ibrahim, El Cherif" uniqKey="Ibrahim E" first="El Chérif" last="Ibrahim">El Chérif Ibrahim</name><name sortKey="Pelletier, Florence" sort="Pelletier, Florence" uniqKey="Pelletier F" first="Florence" last="Pelletier">Florence Pelletier</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Liu, Bing" sort="Liu, Bing" uniqKey="Liu B" first="Bing" last="Liu">Bing Liu</name></region><name sortKey="Carr, Vaughan" sort="Carr, Vaughan" uniqKey="Carr V" first="Vaughan" last="Carr">Vaughan Carr</name><name sortKey="Kelly, Brian" sort="Kelly, Brian" uniqKey="Kelly B" first="Brian" last="Kelly">Brian Kelly</name></country><country name="Sri Lanka"><noRegion><name sortKey="Kumarasinghe, Nishantha" sort="Kumarasinghe, Nishantha" uniqKey="Kumarasinghe N" first="Nishantha" last="Kumarasinghe">Nishantha Kumarasinghe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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